The Role of the Niemann-Pick Disease, Type C1 Protein in Adipocyte Insulin Action

The Niemann-Pick disease, type C1 (NPC1) gene encodes a transmembrane protein involved in cholesterol efflux from the lysosome. SNPs within NPC1 have been associated with obesity and type 2 diabetes, and mice heterozygous or null for NPC1 are insulin resistant. However, the molecular mechanism under...

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Detalles Bibliográficos
Autores principales: Fletcher, Rachael, Gribben, Christopher, Ma, Xuiquan, Burchfield, James G., Thomas, Kristen C., Krycer, James R., James, David E., Fazakerley, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994084/
https://www.ncbi.nlm.nih.gov/pubmed/24752197
http://dx.doi.org/10.1371/journal.pone.0095598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994084/
https://www.ncbi.nlm.nih.gov/pubmed/24752197
http://dx.doi.org/10.1371/journal.pone.0095598

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