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The Variable Hinge Region of Novel PKCs Determines Localization to Distinct Regions of the Immunological Synapse
The immunological synapse (IS) formed between a T cell and its cognate antigen-presenting cell (APC) enables the directional secretion of cytolytic and inflammatory molecules. Synaptic architecture is established in part by a two-step cascade of novel protein kinase C (nPKC) isozymes. PKCε and PKCη...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994095/ https://www.ncbi.nlm.nih.gov/pubmed/24751783 http://dx.doi.org/10.1371/journal.pone.0095531 |