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The Variable Hinge Region of Novel PKCs Determines Localization to Distinct Regions of the Immunological Synapse

The immunological synapse (IS) formed between a T cell and its cognate antigen-presenting cell (APC) enables the directional secretion of cytolytic and inflammatory molecules. Synaptic architecture is established in part by a two-step cascade of novel protein kinase C (nPKC) isozymes. PKCε and PKCη...

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Detalles Bibliográficos
Autores principales: Basu, Roshni, Chen, Yuedan, Quann, Emily J., Huse, Morgan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994095/
https://www.ncbi.nlm.nih.gov/pubmed/24751783
http://dx.doi.org/10.1371/journal.pone.0095531

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