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Development of a Cell-Based Assay Measuring the Activation of FcγRIIa for the Characterization of Therapeutic Monoclonal Antibodies

Antibody-dependent cellular cytotoxicity (ADCC) is one of the important mechanisms of action of the targeting of tumor cells by therapeutic monoclonal antibodies (mAbs). Among the human Fcγ receptors (FcγRs), FcγRIIIa is well known as the only receptor expressed in natural killer (NK) cells, and it...

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Detalles Bibliográficos
Autores principales: Tada, Minoru, Ishii-Watabe, Akiko, Suzuki, Takuo, Kawasaki, Nana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994145/
https://www.ncbi.nlm.nih.gov/pubmed/24752341
http://dx.doi.org/10.1371/journal.pone.0095787