E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

The protein optineurin coded by OPTN gene is involved in several functions including regulation of endocytic trafficking, autophagy and signal transduction. Certain missense mutations in the gene OPTN cause normal tension glaucoma. A glaucoma-causing mutant of optineurin, E50K, induces death selecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Chalasani, Madhavi Latha Somaraju, Kumari, Asha, Radha, Vegesna, Swarup, Ghanshyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994150/
https://www.ncbi.nlm.nih.gov/pubmed/24752605
http://dx.doi.org/10.1371/journal.pone.0095758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994150/
https://www.ncbi.nlm.nih.gov/pubmed/24752605
http://dx.doi.org/10.1371/journal.pone.0095758

Ejemplares similares