Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System

We have previously reported the genetic correction of Huntington’s disease (HD) patient-derived induced pluripotent stem cells using traditional homologous recombination (HR) approaches. To extend this work, we have adopted a CRISPR-based genome editing approach to improve the efficiency of recombin...

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Detalles Bibliográficos
Autores principales: An, Mahru C., O'Brien, Robert N., Zhang, Ningzhe, Patra, Biranchi N., De La Cruz, Michael, Ray, Animesh, Ellerby, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994193/
https://www.ncbi.nlm.nih.gov/pubmed/24761311
http://dx.doi.org/10.1371/currents.hd.0242d2e7ad72225efa72f6964589369a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994193/
https://www.ncbi.nlm.nih.gov/pubmed/24761311
http://dx.doi.org/10.1371/currents.hd.0242d2e7ad72225efa72f6964589369a

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