Amplification of Aminoglycoside Resistance Gene aphA1 in Acinetobacter baumannii Results in Tobramycin Therapy Failure

Gene amplification is believed to play an important role in antibiotic resistance but has been rarely documented in clinical settings because of its unstable nature. We report a rise in MICs from 0.5 to 16 μg/ml in successive Acinetobacter baumannii isolated over 4 days from a patient being treated...

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Detalles Bibliográficos
Autores principales: McGann, Patrick, Courvalin, Patrice, Snesrud, Erik, Clifford, Robert J., Yoon, Eun-Jeong, Onmus-Leone, Fatma, Ong, Ana C., Kwak, Yoon I., Grillot-Courvalin, Catherine, Lesho, Emil, Waterman, Paige E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994513/
https://www.ncbi.nlm.nih.gov/pubmed/24757213
http://dx.doi.org/10.1128/mBio.00915-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994513/
https://www.ncbi.nlm.nih.gov/pubmed/24757213
http://dx.doi.org/10.1128/mBio.00915-14

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