DNA Damage: Quantum Mechanics/Molecular Mechanics Study on the Oxygen Binding and Substrate Hydroxylation Step in AlkB Repair Enzymes

AlkB repair enzymes are important nonheme iron enzymes that catalyse the demethylation of alkylated DNA bases in humans, which is a vital reaction in the body that heals externally damaged DNA bases. Its mechanism is currently controversial and in order to resolve the catalytic mechanism of these en...

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Detalles Bibliográficos
Autores principales: Quesne, Matthew G, Latifi, Reza, Gonzalez-Ovalle, Luis E, Kumar, Devesh, de Visser, Sam P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-VCH Verlag GmbH & Co 2014
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994944/
https://www.ncbi.nlm.nih.gov/pubmed/24339041
http://dx.doi.org/10.1002/chem.201303282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994944/
https://www.ncbi.nlm.nih.gov/pubmed/24339041
http://dx.doi.org/10.1002/chem.201303282

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