Grg3/TLE3 and Grg1/TLE1 Induce Monohormonal Pancreatic β-Cells While Repressing α-Cell Functions

In the pancreas, α- and β-cells possess a degree of plasticity. In vitro differentiation of pluripotent cells yields mostly α- and polyhormonal β-like cells, indicating a gap in understanding of how functional monohormonal β-cells are formed and of the endogenous repressive mechanisms used to mainta...

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Detalles Bibliográficos
Autores principales: Metzger, David E., Liu, Chengyang, Ziaie, Amin Sam, Naji, Ali, Zaret, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994953/
https://www.ncbi.nlm.nih.gov/pubmed/24487024
http://dx.doi.org/10.2337/db13-0867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994953/
https://www.ncbi.nlm.nih.gov/pubmed/24487024
http://dx.doi.org/10.2337/db13-0867

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