Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

Hepatic ketogenesis plays an important role in catabolism of fatty acids during fasting along with dietary lipid overload, but the mechanisms regulating this process remain poorly understood. Here, we show that Cdc2-like kinase 2 (Clk2) suppresses fatty acid oxidation and ketone body production duri...

Descripción completa

Detalles Bibliográficos
Autores principales: Tabata, Mitsuhisa, Rodgers, Joseph T., Hall, Jessica A., Lee, Yoonjin, Jedrychowski, Mark P., Gygi, Steven P., Puigserver, Pere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994960/
https://www.ncbi.nlm.nih.gov/pubmed/24458359
http://dx.doi.org/10.2337/db13-1304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994960/
https://www.ncbi.nlm.nih.gov/pubmed/24458359
http://dx.doi.org/10.2337/db13-1304

Ejemplares similares