Proinsulin-Transferrin Fusion Protein as a Novel Long-Acting Insulin Analog for the Inhibition of Hepatic Glucose Production

Proinsulin-transferrin (ProINS-Tf) fusion protein was evaluated for its in vivo pharmacokinetics, efficacy, and mechanism. Our previous studies have shown that ProINS-Tf was converted to active insulin-transferrin (INS-Tf) via the transferrin (Tf)-receptor–mediated pathway in hepatoma cells. We hypo...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Shao, Juntang, Zaro, Jennica L., Shen, Wei-Chiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994961/
https://www.ncbi.nlm.nih.gov/pubmed/24353179
http://dx.doi.org/10.2337/db13-0973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994961/
https://www.ncbi.nlm.nih.gov/pubmed/24353179
http://dx.doi.org/10.2337/db13-0973

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