A 129-kb Deletion on Chromosome 12 Confers Substantial Protection Against Rheumatoid Arthritis, Implicating the Gene SLC2A3

We describe a copy-number variant (CNV) for which deletion alleles confer a protective affect against rheumatoid arthritis (RA). This CNV reflects net unit deletions and expansions to a normal two-unit tandem duplication located on human chr12p13.31, a region with conserved synteny to the rat RA sus...

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Detalles Bibliográficos
Autores principales: Veal, Colin D, Reekie, Katherine E, Lorentzen, Johnny C, Gregersen, Peter K, Padyukov, Leonid, Brookes, Anthony J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995011/
https://www.ncbi.nlm.nih.gov/pubmed/24178905
http://dx.doi.org/10.1002/humu.22471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995011/
https://www.ncbi.nlm.nih.gov/pubmed/24178905
http://dx.doi.org/10.1002/humu.22471

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