Cargando…
Genetic Exploration of the Exit from Self-Renewal Using Haploid Embryonic Stem Cells
Self-renewal circuitry in embryonic stem cells (ESCs) is increasingly defined. How the robust pluripotency program is dissolved to enable fate transition is less appreciated. Here we develop a forward genetic approach using haploid ESCs. We created libraries of transposon integrations and screened f...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995090/ https://www.ncbi.nlm.nih.gov/pubmed/24412312 http://dx.doi.org/10.1016/j.stem.2013.12.008 |