Genetic Exploration of the Exit from Self-Renewal Using Haploid Embryonic Stem Cells

Self-renewal circuitry in embryonic stem cells (ESCs) is increasingly defined. How the robust pluripotency program is dissolved to enable fate transition is less appreciated. Here we develop a forward genetic approach using haploid ESCs. We created libraries of transposon integrations and screened f...

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Detalles Bibliográficos
Autores principales: Leeb, Martin, Dietmann, Sabine, Paramor, Maike, Niwa, Hitoshi, Smith, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995090/
https://www.ncbi.nlm.nih.gov/pubmed/24412312
http://dx.doi.org/10.1016/j.stem.2013.12.008

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