Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

OBJECTIVE: FBXW7 encodes the substrate recognition component of a ubiquitin ligase that degrades targets such as Notch1, c-Jun, c-Myc and cyclin E. FBXW7 mutations occur in several tumour types, including colorectal cancers. The FBXW7 mutation spectrum in cancers is unusual. Some tumours have bialle...

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Detalles Bibliográficos
Autores principales: Davis, Hayley, Lewis, Annabelle, Behrens, Axel, Tomlinson, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Colon
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995284/
https://www.ncbi.nlm.nih.gov/pubmed/23676439
http://dx.doi.org/10.1136/gutjnl-2013-304719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995284/
https://www.ncbi.nlm.nih.gov/pubmed/23676439
http://dx.doi.org/10.1136/gutjnl-2013-304719

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