Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation

BACKGROUND: MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of high...

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Detalles Bibliográficos
Autores principales: Velho, Sérgia, Pinto, Ana, Licastro, Danilo, Oliveira, Maria José, Sousa, Filipa, Stupka, Elia, Seruca, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995575/
https://www.ncbi.nlm.nih.gov/pubmed/24628919
http://dx.doi.org/10.1186/1471-2407-14-182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995575/
https://www.ncbi.nlm.nih.gov/pubmed/24628919
http://dx.doi.org/10.1186/1471-2407-14-182

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