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Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
BACKGROUND: MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of high...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995575/ https://www.ncbi.nlm.nih.gov/pubmed/24628919 http://dx.doi.org/10.1186/1471-2407-14-182 |