GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells

GPBAR1/TGR5 is a novel plasma membrane-bound G protein–coupled bile acid (BA) receptor. BAs are known to induce the expression of inflammatory cytokines in the liver with unknown mechanism. Here we show that without other external stimuli, TGR5 activation alone induced the expression of interleukin...

Descripción completa

Detalles Bibliográficos
Autores principales: Lou, Guiyu, Ma, Xiaoxiao, Fu, Xianghui, Meng, Zhipeng, Zhang, Wenyu, Wang, Yan-Dong, Van Ness, Carl, Yu, Donna, Xu, Rongzhen, Huang, Wendong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995640/
https://www.ncbi.nlm.nih.gov/pubmed/24755711
http://dx.doi.org/10.1371/journal.pone.0093567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995640/
https://www.ncbi.nlm.nih.gov/pubmed/24755711
http://dx.doi.org/10.1371/journal.pone.0093567

Ejemplares similares