Heterologous Prime-Boost Vaccination with MF59-Adjuvanted H5 Vaccines Promotes Antibody Affinity Maturation towards the Hemagglutinin HA1 Domain and Broad H5N1 Cross-Clade Neutralization

In an open label clinical study (2007), MF59-adjuvanted hemagglutinin (HA) vaccine from H5N1-A/Vietnam/1194/2004 (clade 1) was administered to subjects previously vaccinated (primed) with clade 0 H5N3 (A/duck/Singapore/97) vaccine at least 6 years earlier (in 1999 or 2001). The primed individuals re...

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Detalles Bibliográficos
Autores principales: Khurana, Surender, Coyle, Elizabeth M., Dimitrova, Milena, Castellino, Flora, Nicholson, Karl, Giudice, Giuseppe Del, Golding, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995799/
https://www.ncbi.nlm.nih.gov/pubmed/24755693
http://dx.doi.org/10.1371/journal.pone.0095496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995799/
https://www.ncbi.nlm.nih.gov/pubmed/24755693
http://dx.doi.org/10.1371/journal.pone.0095496

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