Acute Liver Failure in Rats Activates Glutamine-Glutamate Cycle but Declines Antioxidant Enzymes to Induce Oxidative Stress in Cerebral Cortex and Cerebellum

BACKGROUND AND PURPOSE: Liver dysfunction led hyperammonemia (HA) causes a nervous system disorder; hepatic encephalopathy (HE). In the brain, ammonia induced glutamate-excitotoxicity and oxidative stress are considered to play important roles in the pathogenesis of HE. The brain ammonia metabolism...

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Detalles Bibliográficos
Autores principales: Singh, Santosh, Mondal, Papia, Trigun, Surendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995888/
https://www.ncbi.nlm.nih.gov/pubmed/24755687
http://dx.doi.org/10.1371/journal.pone.0095855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995888/
https://www.ncbi.nlm.nih.gov/pubmed/24755687
http://dx.doi.org/10.1371/journal.pone.0095855

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