Effect of Proline Analogues on Activity of Human Prolyl Hydroxylase and the Regulation of HIF Signal Transduction Pathway

Hypoxia inducible factor 1 (HIF-1) plays a pivotal role in cellular responses to hypoxia. Prolyl hydroxylase 3 (PHD3) degrades HIF-1α under normoxic conditions through the hydroxylation of HIF-1α for proteolysis. Inhibiting PHD3 activity is crucial for up-regulating HIF-1α, thereby acting as a poten...

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Detalles Bibliográficos
Autores principales: Ma, Xiaoyan, Wang, Xiaoxin, Cao, Jing, Geng, Zhirong, Wang, Zhilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995910/
https://www.ncbi.nlm.nih.gov/pubmed/24755992
http://dx.doi.org/10.1371/journal.pone.0095692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995910/
https://www.ncbi.nlm.nih.gov/pubmed/24755992
http://dx.doi.org/10.1371/journal.pone.0095692

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