Protection of Pyruvate against Glutamate Excitotoxicity Is Mediated by Regulating DAPK1 Protein Complex

The neuroprotective activity of pyruvate has been confirmed in previous in vivo and in vitro studies. Here, we report a novel mechanism that pyruvate prevents SH-SY5Y cells from glutamate excitotoxicity by regulating death-associated protein kinase 1 (DAPK1) protein complex. Our results showed pyruv...

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Detalles Bibliográficos
Autores principales: Tian, Jingwei, Cheng, Jucan, Zhang, Jianzhao, Ye, Liang, Zhang, Fangxi, Dong, Qiuju, Wang, Hongbo, Fu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995922/
https://www.ncbi.nlm.nih.gov/pubmed/24755839
http://dx.doi.org/10.1371/journal.pone.0095777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995922/
https://www.ncbi.nlm.nih.gov/pubmed/24755839
http://dx.doi.org/10.1371/journal.pone.0095777

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