SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

SARS coronavirus (SARS-CoV) develops an antagonistic mechanism by which to evade the antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like protease (PLpro) inhibits activation of the IRF3 pathway, which would normally elicit a robust IFN response, but the mec...

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Detalles Bibliográficos
Autores principales: Chen, Xiaojuan, Yang, Xingxing, Zheng, Yang, Yang, Yudong, Xing, Yaling, Chen, Zhongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996160/
https://www.ncbi.nlm.nih.gov/pubmed/24622840
http://dx.doi.org/10.1007/s13238-014-0026-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996160/
https://www.ncbi.nlm.nih.gov/pubmed/24622840
http://dx.doi.org/10.1007/s13238-014-0026-3

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