Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays

Understanding therapeutic mechanisms of drug anticancer cytotoxicity represents a key challenge in preclinical testing. Here we have performed a meta-analysis of publicly available tumor cell line growth inhibition assays (~ 70 assays from 6 independent experimental groups covering ~ 500 000 molecul...

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Detalles Bibliográficos
Autores principales: Knight, Richard A., Gostev, Mikhail, Ilisavskii, Sergei, Willis, Anne E., Melino, Gerry, Antonov, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996666/
https://www.ncbi.nlm.nih.gov/pubmed/24553133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996666/
https://www.ncbi.nlm.nih.gov/pubmed/24553133

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