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Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo

Recent studies suggest a positive correlation between glycogen synthase kinase-3 (GSK-3) activation and tumor growth. Currently, it is unclear how both Akt that inhibits GSK-3 and active GSK-3 are maintained concurrently in tumor cells. We investigated the role of GSK-3 and the existence of an Akt-r...

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Detalles Bibliográficos
Autores principales:	Goc, Anna, Al-Husein, Belal, Katsanevas, Katerina, Steinbach, Alison, Lou, Uvette, Sabbineni, Harika, DeRemer, David L., Somanath, Payaningal R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996673/ https://www.ncbi.nlm.nih.gov/pubmed/24519956

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