Negative Regulation of Hif1a Expression and T(H)17 Differentiation by Hypoxia Regulated miR-210

MicroRNA-210 (miR-210) is a signature microRNA of hypoxia. We found robust increase (>100-fold) of miR-210 abundance in activated T cells, especially in the T(H)17 lineage. Hypoxia synergized with T cell receptor (TCR)–CD28 stimulation to accelerate and increase the magnitude of Mir210 expression...

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Detalles Bibliográficos
Autores principales: Wang, Haopeng, Flach, Henrik, Onizawa, Michio, Wei, Lai, McManus, Michael T, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996831/
https://www.ncbi.nlm.nih.gov/pubmed/24608041
http://dx.doi.org/10.1038/ni.2846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996831/
https://www.ncbi.nlm.nih.gov/pubmed/24608041
http://dx.doi.org/10.1038/ni.2846

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