Enhanced hypoglycemic effect of biotin-modified liposomes loading insulin: effect of formulation variables, intracellular trafficking, and cytotoxicity

Peroral protein/peptide delivery has been one of the most challenging, but encouraging topics in pharmaceutics. This article was intended to explore the potential of biotin-modified liposomes (BLPs) as oral insulin delivery carriers. By incorporating biotin-DSPE into the lipid bilayer, we prepared B...

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Detalles Bibliográficos
Autores principales: Zhang, Xingwang, Qi, Jianping, Lu, Yi, Hu, Xiongwei, He, Wei, Wu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996857/
https://www.ncbi.nlm.nih.gov/pubmed/24739082
http://dx.doi.org/10.1186/1556-276X-9-185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996857/
https://www.ncbi.nlm.nih.gov/pubmed/24739082
http://dx.doi.org/10.1186/1556-276X-9-185

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