Inhibition of phosphoinositide 3-kinase/Akt pathway decreases hypoxia inducible factor-1α expression and increases therapeutic efficacy of paclitaxel in human hypoxic gastric cancer cells

The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway plays an important role in cell proliferation, transformation, apoptosis, tumor growth and angiogenesis. Paclitaxel is commonly used to treat multiple human malignancies; however, the underlying mechanisms of paclitaxel in gastric cancer...

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Detalles Bibliográficos
Autores principales: ZHANG, JING, GUO, HUA, ZHU, JIN-SHUI, YANG, YU-CHEN, CHEN, WEI-XIONG, CHEN, NI-WEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997665/
https://www.ncbi.nlm.nih.gov/pubmed/24765145
http://dx.doi.org/10.3892/ol.2014.1963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997665/
https://www.ncbi.nlm.nih.gov/pubmed/24765145
http://dx.doi.org/10.3892/ol.2014.1963

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