An Asp49 Phospholipase A(2) from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E(2) Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages

Phospholipases A(2) (PLA(2)) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA(2) named MT-III leads to prostaglandin (PG)E(2) biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Herein, we explored the molecular mec...

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Detalles Bibliográficos
Autores principales: Moreira, Vanessa, Lomonte, Bruno, Vinolo, Marco Aurélio Ramirez, Curi, Rui, Gutiérrez, José María, Teixeira, Catarina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997854/
https://www.ncbi.nlm.nih.gov/pubmed/24808633
http://dx.doi.org/10.1155/2014/105879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997854/
https://www.ncbi.nlm.nih.gov/pubmed/24808633
http://dx.doi.org/10.1155/2014/105879

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