Single cell imaging of Bruton's Tyrosine Kinase using an irreversible inhibitor

A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time. We synthesized a fluorescent, irreversible BTK binder based on the drug Ibrutinib and characterized its...

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Detalles Bibliográficos
Autores principales: Turetsky, Anna, Kim, Eunha, Kohler, Rainer H., Miller, Miles A., Weissleder, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998017/
https://www.ncbi.nlm.nih.gov/pubmed/24759210
http://dx.doi.org/10.1038/srep04782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998017/
https://www.ncbi.nlm.nih.gov/pubmed/24759210
http://dx.doi.org/10.1038/srep04782

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