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Microglial Cx3cr1 knockout reduces prion disease incubation time in mice
BACKGROUND: Microglia are resident mononuclear phagocytes of the brain that become activated in response to insults including neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and prion disease. In the central nervous system the chemokine Cx3cl1 (Fractalkine) is expressed b...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998043/ https://www.ncbi.nlm.nih.gov/pubmed/24655482 http://dx.doi.org/10.1186/1471-2202-15-44 |