4-Hy­droxy-5-meth­oxy-N,1-dimethyl-2-oxo-N-[4-(tri­fluoro­meth­yl)phen­yl]-1,2-di­hydro­quinoline-3-carboxamide

The title compound, C(20)H(17)F(3)N(2)O(4), named tasquinimod, is a second-generation oral quinoline-3-carboxamide analogue, which is currently in phase III clinical trials for the treatment of metastatic prostate cancer. The quinoline unit is almost planar (r.m.s. deviation of fitted atoms = 0.0075...

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Detalles Bibliográficos
Autores principales: Akinboye, Emmanuel S., Butcher, Ray J., Yildirim, Sema Ozturk, Isaacs, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998412/
https://www.ncbi.nlm.nih.gov/pubmed/24765003
http://dx.doi.org/10.1107/S1600536814003031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998412/
https://www.ncbi.nlm.nih.gov/pubmed/24765003
http://dx.doi.org/10.1107/S1600536814003031

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