Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway

METHODS: Rat neonate cardiomyocytes were cultured and treated with AGEs at different concentration. Two classic autophagy markers, microtubule-associated protein 1 light chain 3 (LC3) and Beclin-1, were detected by western blot assay. The inhibition of RAGE and phosphatidylinositol 3-phosphate kinas...

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Detalles Bibliográficos
Autores principales: Hou, Xuwei, Hu, Zhaohui, Xu, Hanying, Xu, Jian, Zhang, Shunrong, Zhong, Yigang, He, Xiuying, Wang, Ningfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998738/
https://www.ncbi.nlm.nih.gov/pubmed/24725502
http://dx.doi.org/10.1186/1475-2840-13-78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998738/
https://www.ncbi.nlm.nih.gov/pubmed/24725502
http://dx.doi.org/10.1186/1475-2840-13-78

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