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Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts

Osteoblasts not only control bone formation but also support osteoclast differentiation. Here we show the involvement of Kruppel-like factor 4 (KLF4) in the differentiation of osteoclasts and osteoblasts. KLF4 was down-regulated by 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) in osteoblasts. Overex...

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Detalles Bibliográficos
Autores principales: Kim, Jung Ha, Kim, Kabsun, Youn, Bang Ung, Lee, Jongwon, Kim, Inyoung, Shin, Hong-In, Akiyama, Haruhiko, Choi, Yongwon, Kim, Nacksung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998795/
https://www.ncbi.nlm.nih.gov/pubmed/24616223
http://dx.doi.org/10.1083/jcb.201308102