The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

Mitochondrial fusion and structure depend on the dynamin-like GTPase OPA1, whose activity is regulated by proteolytic processing. Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion. Stre...

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Detalles Bibliográficos
Autores principales: Anand, Ruchika, Wai, Timothy, Baker, Michael J., Kladt, Nikolay, Schauss, Astrid C., Rugarli, Elena, Langer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998800/
https://www.ncbi.nlm.nih.gov/pubmed/24616225
http://dx.doi.org/10.1083/jcb.201308006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998800/
https://www.ncbi.nlm.nih.gov/pubmed/24616225
http://dx.doi.org/10.1083/jcb.201308006

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