Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

Through a targeted knockdown (KD) screen of chromatin regulatory genes we identified the EP400 complex components EPC1 and EPC2 as critical oncogenic co-factors in acute myeloid leukemia (AML). EPC1 and EPC2 were required for the clonogenic potential of human AML cells of multiple molecular subtypes...

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Detalles Bibliográficos
Autores principales: Huang, Xu, Spencer, Gary J, Lynch, James T, Ciceri, Filippo, Somerville, Tim D D, Somervaille, Tim C P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998875/
https://www.ncbi.nlm.nih.gov/pubmed/24166297
http://dx.doi.org/10.1038/leu.2013.316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998875/
https://www.ncbi.nlm.nih.gov/pubmed/24166297
http://dx.doi.org/10.1038/leu.2013.316

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