A Coarse-Grained Elastic Network Atom Contact Model and Its Use in the Simulation of Protein Dynamics and the Prediction of the Effect of Mutations

Normal mode analysis (NMA) methods are widely used to study dynamic aspects of protein structures. Two critical components of NMA methods are coarse-graining in the level of simplification used to represent protein structures and the choice of potential energy functional form. There is a trade-off b...

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Detalles Bibliográficos
Autores principales: Frappier, Vincent, Najmanovich, Rafael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998880/
https://www.ncbi.nlm.nih.gov/pubmed/24762569
http://dx.doi.org/10.1371/journal.pcbi.1003569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998880/
https://www.ncbi.nlm.nih.gov/pubmed/24762569
http://dx.doi.org/10.1371/journal.pcbi.1003569

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