Knowledge-based Fragment Binding Prediction

Target-based drug discovery must assess many drug-like compounds for potential activity. Focusing on low-molecular-weight compounds (fragments) can dramatically reduce the chemical search space. However, approaches for determining protein-fragment interactions have limitations. Experimental assays a...

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Detalles Bibliográficos
Autores principales: Tang, Grace W., Altman, Russ B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998881/
https://www.ncbi.nlm.nih.gov/pubmed/24762971
http://dx.doi.org/10.1371/journal.pcbi.1003589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998881/
https://www.ncbi.nlm.nih.gov/pubmed/24762971
http://dx.doi.org/10.1371/journal.pcbi.1003589

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