Feedback Signals in Myelodysplastic Syndromes: Increased Self-Renewal of the Malignant Clone Suppresses Normal Hematopoiesis

Myelodysplastic syndromes (MDS) are triggered by an aberrant hematopoietic stem cell (HSC). It is, however, unclear how this clone interferes with physiologic blood formation. In this study, we followed the hypothesis that the MDS clone impinges on feedback signals for self-renewal and differentiati...

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Detalles Bibliográficos
Autores principales: Walenda, Thomas, Stiehl, Thomas, Braun, Hanna, Fröbel, Julia, Ho, Anthony D., Schroeder, Thomas, Goecke, Tamme W., Rath, Björn, Germing, Ulrich, Marciniak-Czochra, Anna, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998886/
https://www.ncbi.nlm.nih.gov/pubmed/24763223
http://dx.doi.org/10.1371/journal.pcbi.1003599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998886/
https://www.ncbi.nlm.nih.gov/pubmed/24763223
http://dx.doi.org/10.1371/journal.pcbi.1003599

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