20-Hydroxyeicosatetraenoic Acid Impairs Endothelial Insulin Signaling by Inducing Phosphorylation of the Insulin Receptor Substrate-1 at Ser(616)

20-hydroxyeicosatetraenoic acid (20-HETE) induces endothelial dysfunction and is correlated with diabetes. This study was designed to investigate the effects of 20-HETE on endothelial insulin signaling.Human umbilical vein endothelial cells (HUVECs) or C57BL/6J mice were treated with 20-HETE in the...

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Detalles Bibliográficos
Autores principales: Li, Xuguang, Zhao, Gang, Ma, Ben, Li, Rui, Hong, Jiang, Liu, Shaowen, Wang, Dao Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998975/
https://www.ncbi.nlm.nih.gov/pubmed/24763529
http://dx.doi.org/10.1371/journal.pone.0095841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998975/
https://www.ncbi.nlm.nih.gov/pubmed/24763529
http://dx.doi.org/10.1371/journal.pone.0095841

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