Rapamycin Inhibition of Polyposis and Progression to Dysplasia in a Mouse Model

Familial adenomatous polyposis (FAP) is often due to adenomatous polyposis coli (APC) gene germline mutations. Somatic APC defects are found in about 80% of colorectal cancers (CRCs) and adenomas. Rapamycin inhibits mammalian target of rapamycin (mTOR) protein, which is often expressed in human aden...

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Detalles Bibliográficos
Autores principales: Hardiman, Karin M., Liu, Jianhua, Feng, Ying, Greenson, Joel K., Fearon, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999114/
https://www.ncbi.nlm.nih.gov/pubmed/24763434
http://dx.doi.org/10.1371/journal.pone.0096023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999114/
https://www.ncbi.nlm.nih.gov/pubmed/24763434
http://dx.doi.org/10.1371/journal.pone.0096023

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