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Rapamycin Inhibition of Polyposis and Progression to Dysplasia in a Mouse Model
Familial adenomatous polyposis (FAP) is often due to adenomatous polyposis coli (APC) gene germline mutations. Somatic APC defects are found in about 80% of colorectal cancers (CRCs) and adenomas. Rapamycin inhibits mammalian target of rapamycin (mTOR) protein, which is often expressed in human aden...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999114/ https://www.ncbi.nlm.nih.gov/pubmed/24763434 http://dx.doi.org/10.1371/journal.pone.0096023 |