High incidence of female reproductive tract cancers in FA deficient HPV16 transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins

Fanconi anemia (FA) is a rare genetic disorder caused by defects in a DNA damage repair system, the FA pathway. FA patients frequently develop squamous cell carcinoma (SCC) at sites that are associated with HPV-driven cancer including the female reproductive tract. To assess experimentally whether F...

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Detalles Bibliográficos
Autores principales: Park, Jung Wook, Shin, Myeong-Kyun, Lambert, Paul F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999289/
https://www.ncbi.nlm.nih.gov/pubmed/24013229
http://dx.doi.org/10.1038/onc.2013.327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999289/
https://www.ncbi.nlm.nih.gov/pubmed/24013229
http://dx.doi.org/10.1038/onc.2013.327

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