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High incidence of female reproductive tract cancers in FA deficient HPV16 transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins
Fanconi anemia (FA) is a rare genetic disorder caused by defects in a DNA damage repair system, the FA pathway. FA patients frequently develop squamous cell carcinoma (SCC) at sites that are associated with HPV-driven cancer including the female reproductive tract. To assess experimentally whether F...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999289/ https://www.ncbi.nlm.nih.gov/pubmed/24013229 http://dx.doi.org/10.1038/onc.2013.327 |