Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells

The Werner syndrome protein (WRN) is a nuclear protein required for cell growth and proliferation. Loss-of-function mutations in the Werner syndrome gene are associated with the premature onset of age-related diseases. How loss of WRN limits cell proliferation and induces replicative senescence is p...

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Detalles Bibliográficos
Autores principales: Li, Baomin, Iglesias-Pedraz, Juan Manuel, Chen, Leng-Ying, Yin, Fei, Cadenas, Enrique, Reddy, Sita, Comai, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999508/
https://www.ncbi.nlm.nih.gov/pubmed/24757718
http://dx.doi.org/10.1111/acel.12181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999508/
https://www.ncbi.nlm.nih.gov/pubmed/24757718
http://dx.doi.org/10.1111/acel.12181

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