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Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis

Herein, we describe the syntheses of a complex biosynthesis-intermediate analogue of the potent antitumor polyketide borrelidin and of reference molecules to determine the stereoselectivity of the dehydratase of borrelidin polyketide synthase module 3. The target molecules were obtained from a commo...

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Detalles Bibliográficos
Autores principales: Hahn, Frank, Kandziora, Nadine, Friedrich, Steffen, Leadlay, Peter Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999764/
https://www.ncbi.nlm.nih.gov/pubmed/24778714
http://dx.doi.org/10.3762/bjoc.10.55