Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition

BACKGROUND: BRAF is mutated in ∼42% of human melanomas (COSMIC. http://www.sanger.ac.uk/genetics/CGP/cosmic/) and pharmacological BRAF inhibitors such as vemurafenib and dabrafenib achieve dramatic responses in patients whose tumours harbour BRAF(V600) mutations. Objective responses occur in ∼50% of...

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Detalles Bibliográficos
Autores principales: Turajlic, S., Furney, S. J., Stamp, G., Rana, S., Ricken, G., Oduko, Y., Saturno, G., Springer, C., Hayes, A., Gore, M., Larkin, J., Marais, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999800/
https://www.ncbi.nlm.nih.gov/pubmed/24504448
http://dx.doi.org/10.1093/annonc/mdu049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999800/
https://www.ncbi.nlm.nih.gov/pubmed/24504448
http://dx.doi.org/10.1093/annonc/mdu049

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