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Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel
Sea anemone neurotoxins are peptides that interact with Na(+) and K(+) channels, resulting in specific alterations on their functions. Some of these neurotoxins (1ROO, 1BGK, 2K9E, 1BEI) are important for the treatment of about 80 autoimmune disorders because of their specificity for Kv1.3 channel. T...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999815/ https://www.ncbi.nlm.nih.gov/pubmed/24812496 http://dx.doi.org/10.4137/BBI.S13403 |
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author | Sabogal-Arango, Angélica Barreto, George E Ramírez-Sánchez, David González-Mendoza, Juan Barreto, Viviana Morales, Ludis González, Janneth |
author_facet | Sabogal-Arango, Angélica Barreto, George E Ramírez-Sánchez, David González-Mendoza, Juan Barreto, Viviana Morales, Ludis González, Janneth |
author_sort | Sabogal-Arango, Angélica |
collection | PubMed |
description | Sea anemone neurotoxins are peptides that interact with Na(+) and K(+) channels, resulting in specific alterations on their functions. Some of these neurotoxins (1ROO, 1BGK, 2K9E, 1BEI) are important for the treatment of about 80 autoimmune disorders because of their specificity for Kv1.3 channel. The aim of this study was to identify the common residues among these neurotoxins by computational methods, and establish whether there is a pattern useful for the future generation of a treatment for autoimmune diseases. Our results showed eight new key common residues between the studied neurotoxins interacting with a histidine ring and the selectivity filter of the receptor, thus showing a possible pattern of interaction. This knowledge may serve as an input for the design of more promising drugs for autoimmune treatments. |
format | Online Article Text |
id | pubmed-3999815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-39998152014-05-08 Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel Sabogal-Arango, Angélica Barreto, George E Ramírez-Sánchez, David González-Mendoza, Juan Barreto, Viviana Morales, Ludis González, Janneth Bioinform Biol Insights Original Research Sea anemone neurotoxins are peptides that interact with Na(+) and K(+) channels, resulting in specific alterations on their functions. Some of these neurotoxins (1ROO, 1BGK, 2K9E, 1BEI) are important for the treatment of about 80 autoimmune disorders because of their specificity for Kv1.3 channel. The aim of this study was to identify the common residues among these neurotoxins by computational methods, and establish whether there is a pattern useful for the future generation of a treatment for autoimmune diseases. Our results showed eight new key common residues between the studied neurotoxins interacting with a histidine ring and the selectivity filter of the receptor, thus showing a possible pattern of interaction. This knowledge may serve as an input for the design of more promising drugs for autoimmune treatments. Libertas Academica 2014-04-15 /pmc/articles/PMC3999815/ /pubmed/24812496 http://dx.doi.org/10.4137/BBI.S13403 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CCCC-BY-NCNC 3.0 License. |
spellingShingle | Original Research Sabogal-Arango, Angélica Barreto, George E Ramírez-Sánchez, David González-Mendoza, Juan Barreto, Viviana Morales, Ludis González, Janneth Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel |
title | Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel |
title_full | Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel |
title_fullStr | Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel |
title_full_unstemmed | Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel |
title_short | Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel |
title_sort | computational insights of the interaction among sea anemones neurotoxins and kv1.3 channel |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999815/ https://www.ncbi.nlm.nih.gov/pubmed/24812496 http://dx.doi.org/10.4137/BBI.S13403 |
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