Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation

BACKGROUND: The RAS/ERK and PI3K/AKT pathways induce oncogenic gene expression programs and are commonly activated together in cancer cells. Often, RAS/ERK signaling is activated by mutation of the RAS or RAF oncogenes, and PI3K/AKT is activated by loss of the tumor suppressor PTEN. In prostate canc...

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Detalles Bibliográficos
Autores principales: Selvaraj, Nagarathinam, Budka, Justin A, Ferris, Mary W, Jerde, Travis J, Hollenhorst, Peter C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999933/
https://www.ncbi.nlm.nih.gov/pubmed/24642271
http://dx.doi.org/10.1186/1476-4598-13-61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999933/
https://www.ncbi.nlm.nih.gov/pubmed/24642271
http://dx.doi.org/10.1186/1476-4598-13-61

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