Structural transformation induced by locked nucleic acid or 2′–O-methyl nucleic acid site-specific modifications on thrombin binding aptamer

BACKGROUND: Locked nucleic acid (LNA) and 2'–O-methyl nucleic acid (OMeNA) are two of the most extensively studied nucleotide derivatives in the last decades. However, how they affect DNA quadruplex structures remains largely unknown. To explore their possible biological affinities for quadrupl...

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Detalles Bibliográficos
Autores principales: Liu, Bo, Li, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000052/
https://www.ncbi.nlm.nih.gov/pubmed/24642032
http://dx.doi.org/10.1186/1752-153X-8-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000052/
https://www.ncbi.nlm.nih.gov/pubmed/24642032
http://dx.doi.org/10.1186/1752-153X-8-19

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